Right-hander Jimmy Brasoban (0-4) started for the TinCaps (5-14, 35-54 overall), giving up six earned runs in 2 2/3 innings.
The TinCaps tied the game briefly at 1-1 with a run in the third inning.
Ronnie Richardson was walked by Victor Arano, Dustin Peterson singled and after a double play by Jake Bauers, Richardson scored on a single by Franmil Reyes.
The Loons (11-9, 45-45) scored five runs in the third inning, with the big hit being a bases-loaded double from Webster Rivas that scored Paul Hoenecke, Josmar Cordero and Brandon Trinkwon.
The Loons extended their lead on a Cordero solo home run in the fifth and a run from Alex Santana in the sixth.
Arano (4-3) gave up seven hits, one earned run and struck out seven.
The TinCaps out-hit the Loons 11-8 but left 10 men on base. Josh VanMeter, Reynaldo Bruguera, Ryan Miller, Reyes and Peterson all had two hits apiece.
The TinCaps return home for a four-game series against South Bend beginning at 7:05 p.m. today.
After the game, the TinCaps announced that Luis Tejada was transferred from Fort Wayne to Advanced-A Lake Elsinore.