The TinCaps fell 12-5 in the finale of a three-game series against the Lansing Lugnuts in Michigan.
After splitting the first two games, Fort Wayne was looking to win only its second series of the season.
Lansing (16-16) led 8-2 before the TinCaps (13-19) scored three times in the top of the eighth to cut the lead to 8-5. But the Lugnuts came back with four runs in the bottom of the eighth to secure the win.
Fort Wayne committed four errors. Starter Coby Cowgill (2-1) gave up six runs, four earned, in five innings and seven hits.
The TinCaps got back-to-back RBI singles from Fernando Perez and Franmil Reyes in the third to tie the game at 2 against Lugnuts starter Matt Dermody (1-0), who gave up only two runs in 5 2/3 innings. Lansing scored four runs in the fifth and two more in the seventh to open up the 8-2 advantage.
Fort Wayne had 11 hits, with Perez, Reyes, Mallex Smith and Josh VanMeter getting two each.
L.B. Dantzler scored three runs and knocked in three runs for the Lugnuts.