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Associated Press
Boston’s Grady Sizemore hits a three-run home run in the sixth inning off the Yankees’ CC Sabathia, Sizemore’s former teammate in Cleveland.

Red Sox slug way past Yankees

– Grady Sizemore’s big hit against an old friend ensured Jon Lester finally had something to show for an impressive effort.

Sizemore hit a three-run homer in the sixth inning off CC Sabathia, and the Boston Red Sox gave Lester enough run support for his first win of the year, 4-2 over the New York Yankees on Friday night.

“Good to have a rally there in that inning,” Sizemore said. “We’ve kind of struggled with Jon on the mound. It’s nice to pick him up and get some runs for him.”

It wasn’t all positive news for Boston in its first win this season over the rival Yankees. Closer Koji Uehara was held out of the game because he had some right shoulder stiffness when throwing during pregame warmups. Manager John Farrell used Edward Mujica in the ninth instead of Uehara as a precaution.

“We felt it was best to stay away from him,” Farrell said. “It’ll be a day-to-day thing.”

Jonny Gomes led off the sixth with another long ball off Sabathia, and the four-run inning was more runs than Boston had scored for Lester in his first two starts combined (one). Despite a 2.51 ERA coming in, Lester was at risk of falling to 0-3 for the first time.

The left-hander was lifted with two outs in the seventh after Kelly Johnson singled to pull the Yankees within two runs, his first hit in 15 career at-bats against Lester (1-2). Junichi Tazawa relieved with runners at the corners and retired Derek Jeter on a flyout.

Jeter hit leadoff for the Yankees for first time since breaking his left ankle in the 2012 AL championship series opener. He beat out an infield single in four at-bats.

Lester gave up Alfonso Soriano’s homer starting the second and six hits overall. He walked two and struck out six in improving to 12-5 in 27 starts against New York.

“I don’t feel like I threw the ball as well the first two, but sometimes you need games like this to appreciate the ones where you glide through,” Lester said. “This was a little bit of a grinder.”

Tazawa pitched 1 1/3 innings of one-hit relief, and Mujica was perfect in the ninth for his first save with Boston.

Sabathia (1-2) pitched without the controversy that surrounded teammate Michael Pineda in a series-opening 4-1 win Thursday but also without the success. Pineda gave up one run and four hits in six-plus innings but was caught on camera with a brown substance on his hand. Joe Torre, Major League Baseball’s executive vice president for baseball operations, said in a statement Friday that Pineda will not be suspended.

Sabathia was dominant for five innings. He gave up just David Ross’ third-inning double until Gomes led off the sixth with his first homer of the year, on an 89 mph four-seam fastball.

Four batters later, Sizemore crushed an 80 mph slider into right field for a 4-1 lead.

Sizemore and Sabathia were teammates in Cleveland before Sabathia was traded to Milwaukee during the 2008 season.

“You go out and compete, even against friends,” Sabathia said. “Tonight he got the best of me.”

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